SIT1 monoclonal antibody, clone SIT-01 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant SIT1.
Immunogen
Recombinant protein corresponding to partial human SIT1.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts with SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs. It weakly crossreacts with mouse SIT.
Form
Liquid
Conjugation
PE
Concentration
0.1 mg/mL
Isotype
IgG1
Recommend Usage
Flow Cytometry (1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunoprecipitation
Flow Cytometry
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Gene Info — SIT1
Entrez GeneID
27240Gene Name
SIT1
Gene Alias
MGC125908, MGC125909, MGC125910, RP11-331F9.5, SIT
Gene Description
signaling threshold regulating transmembrane adaptor 1
Omim ID
604964Gene Ontology
HyperlinkOther Designations
OTTHUMP00000021333|SHP2 interacting transmembrane adaptor|SHP2-interacting transmembrane adaptor protein|suppression inducing transmembrane adaptor 1
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Interactome
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Disease
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Publication Reference
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Transmembrane adaptor molecules: a new category of lymphoid-cell markers.
Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rudiger T, Angelisova P, Du MQ, Roberton H, Roncador G, Sanchez L, Pozzobon M, Masir N, Barry R, Pileri S, Mason DY, Marafioti T, Horejsi V.
Blood 2005 Sep; 107(1):213.
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Complete sequence, genomic organization, and chromosomal localization of the human gene encoding the SHP2-interacting transmembrane adaptor protein (SIT).
Hubener C, Mincheva A, Lichter P, Schraven B, Bruyns E.
Immunogenetics 2001 May; 53(4):337.
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SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation.
Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B.
The Journal of Experimental Medicine 1999 Apr; 189(8):1181.
Application:IF, Human, HPB-ALL, Jurkat cells.
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Transmembrane adaptor molecules: a new category of lymphoid-cell markers.
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