LAT2 monoclonal antibody, clone NAP-07 (PE)
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant LAT2.
Immunogen
Recombinant protein corresponding to partial human LAT2.
Host
Mouse
Theoretical MW (kDa)
25-30
Reactivity
Human, Mouse
Specificity
This antibody reacts with Non-T cell activation linker (NTAL), also known as LAB (linker of activated B cells), a 25-30 KDa transmembrane adaptor protein present in membrane microdomains (rafts) of B lymphocytes, NK cells and myeloid cells.
Form
Liquid
Conjugation
PE
Concentration
0.1 mg/mL
Isotype
IgG1
Recommend Usage
Flow Cytometry (1:30)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Immunoprecipitation
Flow Cytometry
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Gene Info — LAT2
Entrez GeneID
7462Gene Name
LAT2
Gene Alias
HSPC046, LAB, NTAL, WBSCR15, WBSCR5, WSCR5
Gene Description
linker for activation of T cells family, member 2
Omim ID
605719Gene Ontology
HyperlinkGene Summary
This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000160648|OTTHUMP00000179118|OTTHUMP00000179119|Williams-Beuren syndrome chromosome region 15|Williams-Beuren syndrome chromosome region 5|linker for activation of B cells|linker for activation of T cells family member 2|non-T cell activation lin
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Interactome
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Publication Reference
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Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells.
Lebduska P, Korb J, Tůmová M, Heneberg P, Dráber P.
Journal of Immunological Methods 2007 Dec; 328(1-2):139.
Application：Func, Mouse, Rat, Mouse bone marrow-derived mast cells, Tumor-derived rat basophilic leukemia cells.
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Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
Volná P, Lebduska P, Dráberová L, Símová S, Heneberg P, Boubelík M, Bugajev V, Malissen B, Wilson BS, Horejsí V, Malissen M, Dráber P.
The Journal of Experimental Medicine 2004 Oct; 200(8):1001.
Application：IEM, WB, Mouse, Mouse bone marrow-derived mast cells.
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NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation.
Tkaczyk C, Horejsi V, Iwaki S, Draber P, Samelson LE, Satterthwaite AB, Nahm DH, Metcalfe DD, Gilfillan AM.
Blood 2004 Mar; 104(1):207.
Application：IP-WB, Mouse, Mouse bone marrow–derived mast cells.
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Topography of signaling molecules as detected by electron microscopy on plasma membrane sheets isolated from non-adherent mast cells.
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