TNFRSF10B monoclonal antibody, clone DR5-01-1 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant TNFRSF10B.
Immunogen
Recombinant Fc fusion protein corresponding to partial human TNFRSF10B.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L).
Form
Liquid
Conjugation
FITC
Concentration
0.1 mg/mL
Isotype
IgG1
Recommend Usage
Flow Cytometry (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — TNFRSF10B
Entrez GeneID
8795Gene Name
TNFRSF10B
Gene Alias
CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9
Gene Description
tumor necrosis factor receptor superfamily, member 10b
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq
Other Designations
Fas-like protein|OTTHUMP00000123492|TNF-related apoptosis-inducing ligand receptor 2|TRAIL receptor 2|apoptosis inducing protein TRICK2A/2B|apoptosis inducing receptor TRAIL-R2|cytotoxic TRAIL receptor-2|death domain containing receptor for TRAIL/Apo-2L|d
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Interactome
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Pathway
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Disease
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Publication Reference
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Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death.
Se-Yeon Park, Han-Hee Park, Sang-Yeong Park, Sun Mi Hong, Seongmin Yoon, Michael J Morgan, You-Sun Kim.
Cell Death & Disease 2020 Sep; 11(9):744.
Application:Flow Cyt, Human, HT-29, NCI-H1299 cells.
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TRAIL, caspases and maturation of normal and leukemic myeloid precursors.
Corallini F, Milani D, Nicolin V, Secchiero P.
Leukemia & Lymphoma 2006 Aug; 47(8):1459.
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Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death.
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