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Last updated: 2017/3/26
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ENG monoclonal antibody, clone MEM-226 (FITC)

  • Catalog # : MAB4501
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant ENG.
  • Immunogen:
  • Recombinant protein corresponding to human ENG.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 180
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes CD105 (Endoglin), a 180 KDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
  • Form:
  • Liquid
  • Conjugation:
  • FITC
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.2% BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store in the dark at 4°C. Do not freeze.
    Avoid prolonged exposure to light.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunoprecipitation
  • Flow Cytometry
  • Flow Cytometry
  • Surface staining of HUVEC (human umbilical vein endothelial cells) with ENG monoclonal antibody, clone MEM-226 (FITC) (Cat # MAB4501).
    Total viable cells were used for analysis.
  • Application Image
  • Western Blot
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 2022
  • Gene Name:
  • ENG
  • Gene Alias:
  • CD105,END,FLJ41744,HHT1,ORW,ORW1
  • Gene Description:
  • endoglin
  • Gene Summary:
  • This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • CD105 antigen,OTTHUMP00000022221,Osler-Rendu-Weber syndrome 1
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