ENG monoclonal antibody, clone MEM-226 (FITC)
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More Files
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Flow Cytometry
Surface staining of HUVEC (human umbilical vein endothelial cells) with ENG monoclonal antibody, clone MEM-226 (FITC) (Cat # MAB4501).
Total viable cells were used for analysis.
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant ENG.
Immunogen
Recombinant protein corresponding to human ENG.
Host
Mouse
Theoretical MW (kDa)
180
Reactivity
Human
Specificity
This antibody recognizes CD105 (Endoglin), a 180 KDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Form
Liquid
Conjugation
FITC
Isotype
IgG2a
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunoprecipitation
Flow Cytometry
Surface staining of HUVEC (human umbilical vein endothelial cells) with ENG monoclonal antibody, clone MEM-226 (FITC) (Cat # MAB4501).
Total viable cells were used for analysis. -
Gene Info — ENG
Entrez GeneID
2022Gene Name
ENG
Gene Alias
CD105, END, FLJ41744, HHT1, ORW, ORW1
Gene Description
endoglin
Gene Ontology
HyperlinkGene Summary
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD105 antigen|OTTHUMP00000022221|Osler-Rendu-Weber syndrome 1
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Interactome
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Disease
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Publication Reference
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Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study.
Piao M, Tokunaga O.
Journal of Atherosclerosis and Thrombosis 2006 Apr; 13(2):82.
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Functional role of CD105 in TGF-beta1 signalling in murine and human endothelial cells.
Warrington K, Hillarby MC, Li C, Letarte M, Kumar S.
Anticancer Research 2005 May; 25(3B):1851.
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CD105 inhibits transforming growth factor-beta-Smad3 signalling.
Guo B, Slevin M, Li C, Parameshwar S, Liu D, Kumar P, Bernabeu C, Kumar S.
Anticancer Research 2004 May; 24(3a):1337.
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Significant expression of endoglin (CD105), TGFbeta-1 and TGFbeta R-2 in the atherosclerotic aorta: an immunohistological study.
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