ACRV1 monoclonal antibody, clone Hs-14 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against native ACRV1.
Immunogen
Native purified human ACRV1.
Host
Mouse
Theoretical MW (kDa)
220
Reactivity
Human, Mouse
Specificity
This antibody reacts with a 220 KDa testis-specific human intra-acrosomal protein associated with the membranes of the acrosomal vesicle.
Form
Liquid
Conjugation
FITC
Isotype
IgM
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Flow Cytometry
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Gene Info — ACRV1
Entrez GeneID
56Gene Name
ACRV1
Gene Alias
D11S4365, SP-10, SPACA2
Gene Description
acrosomal vesicle protein 1
Omim ID
102525Gene Ontology
HyperlinkGene Summary
This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans. [provided by RefSeq
Other Designations
sperm protein 10
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Interactome
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Publication Reference
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Monoclonal antibodies against sperm intra-acrosomal antigens as markers for male infertility diagnostics and estimation of spermatogenesis.
Peknicova J, Chladek D, Hozak P.
American Journal of Reproductive Immunology 2005 Jan; 53(1):42.
Application:IF, WB, Human, Human sperm cells.
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[Significance of determination of intra-acrosomal proteins and sperm antibodies in human reproduction].
Pavlásek J, Peknicová J, Ulcová-Gallová Z, Nováková P, Reischig J, Micanová Z, Rokyta Z.
Ceska Gynekol 2004 Jul; 69(4):306.
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Monoclonal antibodies against sperm intra-acrosomal antigens as markers for male infertility diagnostics and estimation of spermatogenesis.
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