SELL monoclonal antibody, clone LT-TD180 (FITC)
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Specifications
Product Description
Mouse monoclonal antibody raised against native SELL.
Immunogen
Native purified SELL from peripheral blood leukocytes.
Host
Mouse
Theoretical MW (kDa)
74-95
Reactivity
Human
Specificity
This antibody reacts with CD62L (L-selectin), a 74-95 KDa single chain type I glycoprotein expressed on most peripheral blood B lymphocytes, T lymphocytes, monocytes and granulocytes; it is also present on a subset of NK cells and certain hematopoietic malignant cells.
Form
Liquid
Conjugation
FITC
Isotype
IgG1
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
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Gene Info — SELL
Entrez GeneID
6402Gene Name
SELL
Gene Alias
CD62L, LAM-1, LAM1, LECAM1, LNHR, LSEL, LYAM1, Leu-8, Lyam-1, PLNHR, TQ1, hLHRc
Gene Description
selectin L
Gene Ontology
HyperlinkGene Summary
SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins. [provided by RefSeq
Other Designations
Leu-8 antigen|leukocyte adhesion molecule-1|lymph node homing receptor|lymphocyte adhesion molecule 1
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Dynamic alterations of membrane tethers stabilize leukocyte rolling on P-selectin.
Ramachandran V, Williams M, Yago T, Schmidtke DW, McEver RP.
PNAS 2004 Sep; 101(37):13519.
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L-selectin stimulation enhances functional expression of surface CXCR4 in lymphocytes: implications for cellular activation during adhesion and migration.
Ding Z, Issekutz TB, Downey GP, Waddell TK.
Blood 2003 Jun; 101(11):4245.
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L-selectin (CD62L) cross-linking signals neutrophil adhesive functions via the Mac-1 (CD11b/CD18) beta 2-integrin.
Simon SI, Burns AR, Taylor AD, Gopalan PK, Lynam EB, Sklar LA, Smith CW.
Journal of Immunology 1995 Aug; 155(3):1502.
Application:Flow Cyt, Func, Human, HUVECs, Neutrophils.
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Dynamic alterations of membrane tethers stabilize leukocyte rolling on P-selectin.
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