GYPA monoclonal antibody, clone HIR2 (FITC)
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of GYPA.
Immunogen
A synthetic peptide corresponding to N-terminus of human GYPA.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes N-terminal portion of glycophorin A (and weakly of glycophorin B). Its antigen is expressed on early erythroblasts, late erythroblasts, erythroblasts, mature erythrocytes and the cells of erythroid cell lines K562 and HEL, but not on all other cells.
Form
Liquid
Conjugation
FITC
Isotype
IgG2b
Recommend Usage
Flow Cytometry (20 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Agglutination
Flow Cytometry
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Gene Info — GYPA
Entrez GeneID
2993Gene Name
GYPA
Gene Alias
CD235a, GPA, GPErik, GPSAT, GpMiIII, HGpMiIII, HGpMiV, HGpMiX, HGpMiXI, HGpSta(C), MN, MNS
Gene Description
glycophorin A (MNS blood group)
Gene Ontology
HyperlinkGene Summary
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq
Other Designations
Mi.V glycoprotein (24 AA)|erythroid-lineage-specific membrane sialoglycoprotein|glycophorin A|glycophorin A (MN blood group)|glycophorin A MNS blood group|glycophorin A, GPA|glycophorin Erik|glycophorin MiI|glycophorin MiIII|glycophorin MiV|glycophorin Mi
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Interactome
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Pathway
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Disease
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Publication Reference
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Inverted erythrocyte membranes demonstrate β2GPI-antiphospholipid antibody interactions and membrane crosslinking.
Bloemen S, Wu XX, Devreese KM, de Laat B, Rand JH, Vasovic LV.
Thrombosis Research 2016 Sep; 146:89.
Application：Flow Cyt, Human, Human erythrocyte.
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Hsa, an adhesin of Streptococcus gordonii DL1, binds to alpha2-3-linked sialic acid on glycophorin A of the erythrocyte membrane.
Yajima A, Urano-Tashiro Y, Shimazu K, Takashima E, Takahashi Y, Konishi K.
Microbiology and Immunology 2008 Feb; 52(2):69.
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Flow cytometric analysis of human bone marrow perfusion cultures: erythroid development and relationship with burst-forming units-erythroid.
Rogers CE, Bradley MS, Palsson BO, Koller MR.
Exp Hematol 1996 Apr; 24(5):597.
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Inverted erythrocyte membranes demonstrate β2GPI-antiphospholipid antibody interactions and membrane crosslinking.
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