CD19 monoclonal antibody, clone LT19 (APC)
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Specification
Product Description
Mouse monoclonal antibody raised against native CD19.
Immunogen
Native purified CD19 from Daudi human Burkitt lymphoma cell line.
Host
Mouse
Theoretical MW (kDa)
95
Reactivity
Human
Specificity
This antibody reacts with CD19 (B4), a 95 KDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
Form
Liquid
Conjugation
APC
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunoprecipitation
Flow Cytometry
Surface staining of human peripheral blood cells with CD19 monoclonal antibody, clone LT19 (APC) (Cat # MAB4369). -
Gene Info — CD19
Entrez GeneID
930Gene Name
CD19
Gene Alias
B4, MGC12802
Gene Description
CD19 molecule
Omim ID
107265Gene Ontology
HyperlinkGene Summary
Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. [provided by RefSeq
Other Designations
B-lymphocyte antigen CD19|CD19 antigen
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Interactome
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Pathway
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Disease
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Publication Reference
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CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritis.
Shi X, Xie C, Chang S, Zhou XJ, Tedder T, Mohan C.
Arthritis and Rheumatism 2007 Sep; 56(9):3057.
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CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features.
Lin CW, Liu TY, Chen SU, Wang KT, Medeiros LJ, Hsu SM.
Blood 2005 Jul; 106(10):3567.
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Strong cytosine-guanosine-independent immunostimulation in humans and other primates by synthetic oligodeoxynucleotides with PyNTTTTGT motifs.
Elias F, Flo J, Lopez RA, Zorzopulos J, Montaner A, Rodriguez JM.
Journal of Immunology 2003 Oct; 171(7):3697.
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CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritis.
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