ANPEP monoclonal antibody, clone WM15 (APC)
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Specification
Product Description
Mouse monoclonal antibody raised against native ANPEP.
Immunogen
Native purified ANPEP from human AML cell.
Host
Mouse
Theoretical MW (kDa)
150
Reactivity
Human, Non-Human Primates
Specificity
This antibody recognizes the human CD13 cell surface glycoprotein, a 150 KDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.
Form
Liquid
Conjugation
APC
Isotype
IgG1
Recommend Usage
Flow Cytometry (10 ul in human blood cells 100 ul in whole blood or 106 cells in a suspension)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store in the dark at 4°C. Do not freeze.
Avoid prolonged exposure to light.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
Immunoprecipitation
Functional Study
Flow Cytometry
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Gene Info — ANPEP
Entrez GeneID
290Gene Name
ANPEP
Gene Alias
APN, CD13, LAP1, PEPN, gp150, p150
Gene Description
alanyl (membrane) aminopeptidase
Omim ID
151530Gene Ontology
HyperlinkGene Summary
Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma. [provided by RefSeq
Other Designations
OTTHUMP00000194690|aminopeptidase M|aminopeptidase N|membrane alanine aminopeptidase|microsomal aminopeptidase
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Interactome
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Pathway
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Disease
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Publication Reference
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CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated.
Favaloro EJ, Browning T, Facey D.
Exp Hematol 1993 Dec; 21(13):1695.
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Myeloid progenitor surface antigen identified by monoclonal antibody.
Bradstock KF, Favaloro EJ, Kabral A, Kerr A, Hughes WG, Musgrove E.
British Journal of Haematology 1985 Sep; 61(1):11.
Application：Flow Cyt, Human, Human normal bone marrow cells.
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Human myeloid differentiation antigens identified by monoclonal antibodies: expression on leukemic cells.
Bradstock KF, Favaloro EJ, Kabral A, Kerr A, Hughes WG, Berndt MC, Musgrove E.
Pathology 1985 Jul; 17(3):392.
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CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated.
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