Mouse monoclonal antibody raised against native FOLH1.
Native purified FOLH1 from pooled human prostate adenocarcinoma tissues.
Prostate specific membrane antigen, extracellular domain. Reacts with human prostate carcinoma tissues and PSMA derived synthetic peptides. Does not react against normal human prostate tissues or to benign prostatic hyperplasia (BPH) tissues. Reactive to PSMA expressed LNCap cell lines.
Protein G chromatography
The optimal working dilution should be determined by the end user.
Lyophilized from 10 mM PBS, pH 7.0
Store at -20°C. After reconstitution with 0.5 mL of deionized water, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq
N-acetylated alpha-linked acidic dipeptidase 1,cell growth-inhibiting protein 27,folate hydrolase 1,folylpoly-gamma-glutamate carboxypeptidase,glutamate carboxylase II,glutamate carboxypeptidase II,membrane glutamate carboxypeptidase,prostate specific mem