KLK3 monoclonal antibody, clone 131-14234
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Specification
Product Description
Mouse monoclonal antibody raised against native KLK3.
Immunogen
Native purified human KLK3.
Host
Mouse
Reactivity
Human
Specificity
human Prostate Specific Antigen (PSA). PSA is a tumor-associated antigen with a molecular weight of 34 KDa. The antigen is found in normal prostatic epithelial lining cells of the ducts and acini, as well as in primary and metastatic prostate carcinoma cells. PSA reactivity may also be found in BPH (benign prostatic hypertrophy), though the pattern of staining is different than that found in carcinoma tissues. The staining pattern ranges from cytoplasmic and secretory in normal and benign prostate to cytoplasmic with membrane in neoplastic prostate.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In 10 mM phosphate buffer, pH 7.4 (150 mM NaCl, 0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
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Gene Info — KLK3
Entrez GeneID
354Gene Name
KLK3
Gene Alias
APS, KLK2A1, PSA, hK3
Gene Description
kallikrein-related peptidase 3
Omim ID
176820Gene Ontology
HyperlinkGene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
P-30 antigen|gamma-seminoprotein|kallikrein 3, (prostate specific antigen)|prostate specific antigen|semenogelase|seminin
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Interactome
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Pathway
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Disease
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