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Last updated: 2016/12/4
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NCSTN monoclonal antibody, clone AT3B2

  • Catalog # : MAB4200
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant NCSTN.
  • Immunogen:
  • Recombinant protein corresponding to amino acids 34-153 of human NCSTN.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Mouse
  • Form:
  • Liquid
  • Isotype:
  • IgG2b, kappa
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • Western blot analysis of mouse brain tissue extracts (80 ug) and probed with NCSTN monoclonal antibody, clone AT3B2 (Cat # MAB4200 ; 1 : 500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
  • ELISA
  • Application Image
  • Western Blot (Tissue lysate)
  • Western Blot (Tissue lysate)
  • enlarge
  • ELISA
  • Gene Information
  • Gene Name:
  • NCSTN
  • Gene Alias:
  • APH2,KIAA0253
  • Gene Description:
  • nicastrin
  • Gene Summary:
  • This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq
  • Other Designations:
  • ATAG1874,OTTHUMP00000031839,anterior pharynx-defective 2
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