GP1BA monoclonal antibody, clone B3222M
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Specification
Product Description
Mouse monoclonal antibody raised against native GP1BA.
Immunogen
Native purified GP1BA from human washed platelets.
Host
Mouse
Reactivity
Human
Specificity
The molecular weight of the recognized antigen is 160KDa. Reacts with glycoprotein Ib on megakaryocytes and platelets. Inhibits the ristocetin-dependent binding of Von Willebrand factor to platelets and ristocetin induced platelet agglutination. Inhibits platelet aggregation induced by Type I collagen and platelet activating factor (PAF). Immunoprecipitates the components of glycoprotein Ib complex.
Form
Lyophilized
Isotype
IgG1
Recommend Usage
Flow Cytometry (2ug/5x106 platelets/test)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS (1mg/mL BSA)
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunoprecipitation
Flow Cytometry
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Gene Info — GP1BA
Entrez GeneID
2811Gene Name
GP1BA
Gene Alias
BSS, CD42B, CD42b-alpha, GP1B, MGC34595
Gene Description
glycoprotein Ib (platelet), alpha polypeptide
Gene Ontology
HyperlinkGene Summary
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq
Other Designations
platelet glycoprotein Ib alpha polypeptide|platelet membrane glycoprotein 1b-alpha subunit
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