ITGA2B monoclonal antibody, clone B3221M
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against native ITGA2B.
Immunogen
Native purified ITGA2B from human platelets.
Host
Mouse
Reactivity
Human
Specificity
Reacts with gpIIb in the intact complex with gpIIIa, but not with IIb or IIIa, separately. Inhibits platelet aggregation induced by thrombin, collagen and ADP. The molecular weight of the recognized complex is 135KDa/95KDa.
Form
Lyophilized
Isotype
IgG1, kappa
Recommend Usage
Flow Cytometry (2ug/5x106 platelets/test)
Immunohistochemistry (Frozen sections) (1:50-1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS (1mg/mL BSA)
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Frozen sections)
Immunofluorescence
Flow Cytometry
-
Gene Info — ITGA2B
Entrez GeneID
3674Gene Name
ITGA2B
Gene Alias
CD41, CD41B, GP2B, GPIIb, GTA, HPA3
Gene Description
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Gene Ontology
HyperlinkGene Summary
ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq
Other Designations
integrin alpha 2b|platelet fibrinogen receptor, alpha subunit|platelet-specific antigen BAK
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
The platelet membrane glycoprotein IIb-IIIa complex.
Phillips DR, Charo IF, Parise LV, Fitzgerald LA.
Blood 1988 Apr; 74(4):831.
-
Monoclonal antibodies against platelet membrane glycoproteins. Characterization and effect on platelet function.
McGregor JL, Brochier J, Wild F, Follea G, Trzeciak MC, James E, Dechavanne M, McGregor L, Clemetson KJ.
European Journal of Biochemistry 1983 Mar; 131(2):427.
Application:AFC, FME, IP, Human, Human platelets.
-
The platelet membrane glycoprotein IIb-IIIa complex.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com