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Last updated: 2017/6/25
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ITGAM monoclonal antibody, clone BEAR-1

  • Catalog # : MAB4125
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ITGAM.
  • Immunogen:
  • Native purified ITGAM from purified human monocytes.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Reacts with monocytes, polynuclear and null cells. The recognized structure is the alpha chain of a heterodimer glycoprotein of Mw 165kD (alpha chain) and 95kD (beta chain).
  • Form:
  • Lyophilized
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Flow Cytometry (2ug/5x105 cells/test)
    Immunohistochemistry (Frozen sections) (1:25-1:50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS (1mg/mL BSA)
  • Storage Instruction:
  • Store at 4°C on dry atmosphere.
    After reconstitution with deionized water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3684
  • Gene Name:
  • ITGAM
  • Gene Alias:
  • CD11B,CR3A,MAC-1,MAC1A,MGC117044,MO1A,SLEB6
  • Gene Description:
  • integrin, alpha M (complement component 3 receptor 3 subunit)
  • Gene Summary:
  • This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • antigen CD11b (p170),complement component receptor 3, alpha,integrin alpha M,macrophage antigen alpha polypeptide,neutrophil adherence receptor alpha-M subunit
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