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Last updated: 2017/8/13
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ITGAE monoclonal antibody, clone 2G5.1

  • Catalog # : MAB4124
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native ITGAE.
  • Immunogen:
  • Native purified ITGAE from human intestinal lymphocyte (HML1).
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • The CD103 antigen is a heterodimer comprising a 150KDa alpha chain and a 120KDa beta chain. HML-1 antigen is a new member of the integrin family of leukocyte adhesion molecules containing the beta7 subunit. This antibody stains all the various subsets of human intra-epithelial lymphocytes (IEL) as well as 40% of lamina propria T cells, 30% of mesenteric lymphoblasts and some lymphocytes in other mucosae. This antibody labels less than 0.1% bone marrow cells and less than 0.7% PBL.
  • Form:
  • Lyophilized
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Flow Cytometry (2ug/5x105 cells/test)
    Immunohistochemistry (Frozen sections) (1:50-1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS (1mg/mL BSA)
  • Storage Instruction:
  • Store at 4°C on dry atmosphere.
    After reconstitution with deionized water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3682
  • Gene Name:
  • ITGAE
  • Gene Alias:
  • CD103,HUMINAE,MGC141996
  • Gene Description:
  • integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
  • Gene Summary:
  • Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq
  • Other Designations:
  • HML-1 antigen,antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide,integrin alpha-IEL,integrin, alpha E
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