Mouse monoclonal antibody raised against native ITGAE.
Native purified ITGAE from human intestinal lymphocyte (HML1).
The CD103 antigen is a heterodimer comprising a 150KDa alpha chain and a 120KDa beta chain. HML-1 antigen is a new member of the integrin family of leukocyte adhesion molecules containing the beta7 subunit. This antibody stains all the various subsets of human intra-epithelial lymphocytes (IEL) as well as 40% of lamina propria T cells, 30% of mesenteric lymphoblasts and some lymphocytes in other mucosae. This antibody labels less than 0.1% bone marrow cells and less than 0.7% PBL.
Flow Cytometry (2ug/5x105 cells/test) Immunohistochemistry (Frozen sections) (1:50-1:100) The optimal working dilution should be determined by the end user.
Lyophilized from PBS (1mg/mL BSA)
Store at 4°C on dry atmosphere. After reconstitution with deionized water, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. [provided by RefSeq
HML-1 antigen,antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide,integrin alpha-IEL,integrin, alpha E