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Last updated: 2016/12/4
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LAT monoclonal antibody, clone LAT-01

  • Catalog # : MAB3865
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant LAT.
  • Immunogen:
  • Recombinant protein corresponding to cytoplasmic region of human LAT.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 36-38
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with Linker for activation of T cells (LAT), a 36-38 KDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunoprecipitation
  • Flow Cytometry
  • Flow Cytometry
  • Flow Cytometry analysis of LAT expression in human peripheral blood lymphocytes (PBL) using LAT monoclonal antibody, clone LAT-01 (Cat # MAB3865) (surface markers were stained prior to intracellular staining of human LAT).
    Panel A : gate on CD4+ cells.
    Panel B : gate on CD8+ cells.
  • Application Image
  • Western Blot
  • Immunoprecipitation
  • Gene Information
  • Gene Name:
  • LAT
  • Gene Alias:
  • LAT1,pp36
  • Gene Description:
  • linker for activation of T cells
  • Gene Summary:
  • The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • 36 kDa phospho-tyrosine adaptor protein
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