CD6 monoclonal antibody, clone MEM-98
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against native CD6.
Immunogen
Native purified human CD6.
Host
Mouse
Theoretical MW (kDa)
100-130
Reactivity
Human
Specificity
This antibody reacts with CD6, a 100-130 kD single chain transmembrane glycoprotein expressed on T and B lymphocytes subsets, thymocytes, and acute lymphocytic leukemia cells.
Form
Liquid
Purification
Protein A purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (10 ug/mL)
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoprecipitation
Flow Cytometry
Surface staining of human peripheral blood cells with CD6 monoclonal antibody, clone MEM-98 (Cat # MAB3841)-FITC. -
Gene Info — CD6
Entrez GeneID
923Gene Name
CD6
Gene Alias
FLJ44171, TP120
Gene Description
CD6 molecule
Omim ID
186720Gene Ontology
HyperlinkGene Summary
CD6 is a monomeric 105- or 130-kD membrane glycoprotein that is involved in T-cell activation. The size difference between the 2 CD6 forms is due to differences in phosphorylation (Robinson et al., 1995 [PubMed 7589069]).[supplied by OMIM
Other Designations
CD6 antigen
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.
Zimmerman AW, Joosten B, Torensma R, Parnes JR, van Leeuwen FN, Figdor CG.
Blood 2005 Dec; 107(8):3212.
-
CD6 ligation modulates the Bcl-2/Bax ratio and protects chronic lymphocytic leukemia B cells from apoptosis induced by anti-IgM.
Osorio LM, De Santiago A, Aguilar-Santelises M, Mellstedt H, Jondal M.
Blood 1997 Apr; 89(8):2833.
Application:Func, Human, Human B cells.
-
Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102.
Bazil V, Stefanová I, Hilgert I, Kristofová H, Vanĕk S, Bukovský A, Horejsí V.
Folia Biol (Praha) 1989 Jan; 35(5):289.
-
Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com