Mouse monoclonal antibody raised against recombinant SERPINE1.
Recombinant protein corresponding to human SERPINE1.
This mouse monoclonal antibody is specific to plasminogen activator inhibitor-1 (PAI-1) and exhibits inhibitory characteristics. This antibody binds to the F-Helix of PAI-1. This PAI-1 complex acts as a substrate for its target proteinases tPA and uPA.
The optimal working dilution should be determined by the end user.
In 100 mM sodium phosphate buffer, 100 mM NaCl, pH 7.4
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
plasminogen activator inhibitor, type I,plasminogen activator inhibitor-1,serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1