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Last updated: 2017/12/10
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PLAT monoclonal antibody, clone 629-2A153

  • Catalog # : MAB3792
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant PLAT.
  • Immunogen:
  • Recombinant protein corresponding to human PLAT.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This epitope is localized to the heavy chain of human tPA and binds well to both the free and complexed form.
  • Form:
  • Liquid
  • Isotype:
  • IgG
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 50 mM sodium phosphate buffer, 1 mM NaCl, pH 6.6
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Western Blot
  • Lane 1. Human PLAT.
    Lane 2. PLAT in complex with Serpine1.
    Lane 3. Retavase Boehringer/Mannheim (PLAT fragment).
    Lane 4. Retavase in complex with Serpine1.
  • ELISA
  • Application Image
  • ELISA
  • Gene Information
  • Entrez GeneID:
  • 5327
  • Gene Name:
  • PLAT
  • Gene Alias:
  • DKFZp686I03148,T-PA,TPA
  • Gene Description:
  • plasminogen activator, tissue
  • Gene Summary:
  • This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq
  • Other Designations:
  • alteplase,plasminogen activator, tissue type,reteplase,t-plasminogen activator,tissue plasminogen activator (t-PA)
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