Mouse monoclonal antibody raised against synthetic peptide of Beta amyloid.
A synthetic peptide corresponding to amino acids 8-17 of human Beta amyloid.
Reacts with Beta-Amyloid. It reacts with a 4-5 KDa peptide (termed amyloid beta protein/ amyloid A4 or amyloid beta peptide) derived from the amyloid beta precursor protein. This antibody detects extracellular amyloid beta protein within senile plaques and vessel amyloid in formalin-fixed, paraffin-embedded brain of Alzheimer's and Lewy body disease.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)(1:25-1:50) The optimal working dilution should be determined by the end user.
In tissue culture supernatant (0.09% sodium azide)
Store at 4°C.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq