NLRP3 monoclonal antibody, clone Nalpy3-b
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Specifications
Product Description
Mouse monoclonal antibody raised against recombinant NLRP3.
Immunogen
Recombinant protein corresponding to human NLRP3.
Host
Mouse
Reactivity
Human
Specificity
Recognizes human NALP3. Detects endogenous proteins by IP and WB.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:1000)
Immunoprecipitation (1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Frozen sections)
Immunoprecipitation
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Gene Info — NLRP3
Entrez GeneID
114548Gene Name
NLRP3
Gene Alias
AGTAVPRL, AII, AII/AVP, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, FLJ95925, MWS, NALP3, PYPAF1
Gene Description
NLR family, pyrin domain containing 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq
Other Designations
AII/AVP receptor-like|NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3|NACHT, LRR and PYD containing protein 3|OTTHUMP00000038408|OTTHUMP00000038409|OTTHUMP00000038410|PYRIN-containing APAF1-like protein 1|angiotensin/vasopressin receptor
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Interactomes
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Diseases
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Publication Reference
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Novel purine analogues regulate IL-1β release via inhibition of JAK activity in human aortic smooth muscle cells.
Geena V Paramel, Madelene Lindkvist, Berhane A Idosa, Laila Sharon Sebina, Caroline Kardeby, Theano Fotopoulou, Dimitra Pournara, Eftichia Kritsi, Eleni Ifanti, Maria Zervou, Maria Koufaki, Magnus Grenegård, Karin Fransén.
European Journal of Pharmacology 2022 Aug; 929:175128.
Application:WB-Ce, Human, Human aortic smooth muscle cells.
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Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils.
Isak Demirel, Alexander Persson, Annelie Brauner, Eva Särndahl, Robert Kruse, Katarina Persson.
Scientific Reports 2020 Dec; 10(1):21837.
Application:WB-Tr, Human, Human neutrophils.
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Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells.
Demirel I, Persson A, Brauner A, Särndahl E, Kruse R, Persson K.
Frontiers in Cellular and Infection Microbiology 2018 Mar; 8:81.
Application:WB-Ce, Human, Bladder epithelial 5637 cells.
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Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes.
Dai X, Sayama K, Tohyama M, Shirakata Y, Hanakawa Y, Tokumaru S, Yang L, Hirakawa S, Hashimoto K.
The Journal of Allergy and Clinical Immunology 2011 Mar; 127(3):806.
Application:IF, WB, Human, Human keratinocytes.
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Novel purine analogues regulate IL-1β release via inhibition of JAK activity in human aortic smooth muscle cells.
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