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Last updated: 2016/11/27
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NLRP3 monoclonal antibody, clone Nalpy3-a

  • Catalog # : MAB3723
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant NLRP3.
  • Immunogen:
  • Recombinant protein corresponding to human NLRP3.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 75, 130
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes human NALP3. Detects endogenous proteins by ICC and WB.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Western Blot (1:1000)
    Immunocytochemistry (1:100)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunocytochemistry
  • Immunofluorescence
  • Immunofluorescence
  • Immunofluorescence microscopy showing the detection of endogenous NLRP3 in THP-1 cells with NLRP3 monoclonal antibody, clone Nalpy3-a (Cat # MAB3723).
  • Application Image
  • Western Blot
  • Immunocytochemistry
  • Gene Information
  • Gene Name:
  • NLRP3
  • Gene Alias:
  • AGTAVPRL,AII,AII/AVP,AVP,C1orf7,CIAS1,CLR1.1,FCAS,FCU,FLJ95925,MWS,NALP3,PYPAF1
  • Gene Description:
  • NLR family, pyrin domain containing 3
  • Gene Summary:
  • This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq
  • Other Designations:
  • AII/AVP receptor-like,NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3,NACHT, LRR and PYD containing protein 3,OTTHUMP00000038408,OTTHUMP00000038409,OTTHUMP00000038410,PYRIN-containing APAF1-like protein 1,angiotensin/vasopressin receptor
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