Flow cytometry with LTBR monoclonal antibody, clone Carlos-1 (Cat # MAB3721). HEK 293T cells (5 X 105) were mock transfected (thin line) or transfected with an expression plasmid enabling surface expression of the extracellular domain of human LTBR (thick line).
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis. [provided by RefSeq
TNFR superfamily, member 3,lymphotoxin B receptor,lymphotoxin beta receptor,tumor necrosis factor C receptor,tumor necrosis factor receptor superfamily, member 3