Detection of TNFAIP3 by Western blot in HT1080 cells, wild type. Or transfected with TNFAIP3 were activated with 0.1 ug/mL of rhs TNF-alpha for 4 hours. TNFAIP3 monoclonal antibody, clone 8E8.38 (Cat # MAB3716) at 1 : 1,000 dilution.
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses. [provided by RefSeq
OTTHUMP00000017289,tumor necrosis factor inducible protein A20