REN monoclonal antibody, clone 243/3 JG4
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Specification
Product Description
Mouse monoclonal antibody raised against REN.
Immunogen
Human REN.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes recombinant human renin.
Form
Liquid
Isotype
IgG1, kappa
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In BBS
Storage Instruction
Store at 4°C.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — REN
Entrez GeneID
5972Gene Name
REN
Gene Alias
FLJ10761
Gene Description
renin
Gene Ontology
HyperlinkGene Summary
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq
Other Designations
OTTHUMP00000034311|angiotensin-forming enzyme|angiotensinogenase|renin precursor, renal
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Interactome
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