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Last updated: 2016/12/4
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INPP5D monoclonal antibody, clone SHIP-01

  • Catalog # : MAB3645
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of INPP5D.
  • Immunogen:
  • A synthetic peptide corresponding to N-terminus human INPP5D.
  • Host:
  • Mouse
  • Theoretical MW (kDa):
  • 110, 125, 130, 135,
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with SHIP-1, a phosphoinositide phosphatase largely confined to hematopoietic cells. Multiple forms of SHIP-1 have been reported with molecular weights of 110, 125, 130, 135 and 145 KDa.
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Flow Cytometry (2-5 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western Blotting analysis (reducing conditions) of human INPP5D in whole cell lysate of THP-1 (human acute monocytic leukemia cell line).
    Lane 1 : Immunostaining with Isotype mouse IgG1 control.
    Lane 2, 3 : Immunostaining with INPP5D monoclonal antibody, clone SHIP-01 (Cat # MAB3645) Lane 4, 5 : Immunostaining with INPP5D monoclonal antibody, clone SHIP-02 (Cat # MAB3646).
  • Flow Cytometry
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3635
  • Gene Name:
  • INPP5D
  • Gene Alias:
  • MGC104855,MGC142140,MGC142142,SHIP,SHIP1,SIP-145,hp51CN
  • Gene Description:
  • inositol polyphosphate-5-phosphatase, 145kDa
  • Gene Summary:
  • This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq
  • Other Designations:
  • SH2 containing inositol phosphatase,SH2 containing inositol phosphatase, isoform b,p150Ship,signaling inositol polyphosphate 5 phosphatase SIP-145
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