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Last updated: 2016/10/23
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HLA-E monoclonal antibody, clone MEM-E/07

  • Catalog # : MAB3631
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant HLA-E.
  • Immunogen:
  • Recombinant protein corresponding to human HLA-E.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognized native surface-expressed HLA-E, but not denaturated heavy chain of HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on many types of the human cells. The published results revealed that This antibody cross-reacts with some classical MHC Class I molecules (MHC Class Ia) : HLA-B7 (strongly), HLA-B8 (moderately), HLA-B27, -B44 (weakly).
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Immunoprecipitation
  • Flow Cytometry
  • Application Image
  • Immunoprecipitation
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 3133
  • Gene Name:
  • HLA-E
  • Gene Alias:
  • DKFZp686P19218,EA1.2,EA2.1,HLA-6.2,MHC,QA1
  • Gene Description:
  • major histocompatibility complex, class I, E
  • Gene Summary:
  • HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. [provided by RefSeq
  • Other Designations:
  • HLA class I histocompatibility antigen, E alpha chain,MHC HLA-E alpha-1,MHC HLA-E alpha-2.1,MHC class I antigen,OTTHUMP00000029214,lymphocyte antigen
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