FOLH1 monoclonal antibody, clone GCP-05
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant FOLH1.
Immunogen
Recombinant protein corresponding to amino acids 44-750 of human FOLH1.
Host
Mouse
Theoretical MW (kDa)
95-110
Reactivity
Human
Specificity
This antibody recognizes extracellular domain of glutamate carboxypeptidase II (NAALADase, FOLH1, PSMA), an approximately 95-110 KDa transmembrane glycoprotein expressed mainly in tumour neovasculatures, nervous system and jejunum, which is an important prostate tumour marker.
Form
Liquid
Isotype
IgG1
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS, pH 7.4 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunocytochemistry
Immunoprecipitation
Flow Cytometry
Flow cytometric analysis of FOLH1 (PSMA) by various monoclonal antibodies (GCP-01, GCP-02, GCP-04, GCP-05) on LNCaP cell line.
Legend : Green column - 1 ug/mL , LNCaP cell line.
Blue column - 5 ug/mL , LNCaP cell line.
Yellow column - negative cell line.Flow Cytometry
Flow cytometric analysis of FOLH1 (PSMA) using FOLH1 monoclonal antibody, clone GCP-05 (Cat # MAB3611) and goat anti-mouse-PE on LNCaP cell line (positive, Green) and HeLa cells (negative, blue). -
Gene Info — FOLH1
Entrez GeneID
2346Gene Name
FOLH1
Gene Alias
FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP
Gene Description
folate hydrolase (prostate-specific membrane antigen) 1
Omim ID
600934Gene Ontology
HyperlinkGene Summary
This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq
Other Designations
N-acetylated alpha-linked acidic dipeptidase 1|cell growth-inhibiting protein 27|folate hydrolase 1|folylpoly-gamma-glutamate carboxypeptidase|glutamate carboxylase II|glutamate carboxypeptidase II|membrane glutamate carboxypeptidase|prostate specific mem
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Interactome
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Disease
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Publication Reference
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Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells.
Katsetos CD, Dráberová E, Smejkalová B, Reddy G, Bertrand L, de Chadarévian JP, Legido A, Nissanov J, Baas PW, Dráber P.
Neurochemical Research 2007 Aug; 32(8):1387.
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Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.
Sulimenko V, Dráberová E, Sulimenko T, Macurek L, Richterová V, Dráber P, Dráber P.
Journal of Immunology 2006 Jun; 176(12):7243.
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Altered cellular distribution and subcellular sorting of gamma-tubulin in diffuse astrocytic gliomas and human glioblastoma cell lines.
Katsetos CD, Reddy G, Dráberová E, Smejkalová B, Del Valle L, Ashraf Q, Tadevosyan A, Yelin K, Maraziotis T, Mishra OP, Mörk S, Legido A, Nissanov J, Baas PW, de Chadarévian JP, Dráber P.
Journal of Neuropathology and Experimental Neurology 2006 May; 65(5):465.
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Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells.
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