EPHX1 monoclonal antibody, clone AT2E5
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Specification
Product Description
Mouse monoclonal antibody raised against partial recombinant EPHX1.
Immunogen
Recombinant protein corresponding to amino acids 21-455 of human EPHX1.
Host
Mouse
Reactivity
Human, Mouse
Form
Liquid
Purification
Protein G purification
Isotype
IgG2a, kappa
Recommend Usage
ELISA
Immunocytochemistry
Immunofluorescence
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (10% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1: Mouse Liver Tissue lysate, Lane 2: 293T cell lysate, Lane 3: EPHX1 Transfected 293T cell lysate.Immunocytochemistry
Immunofluorescence
Immunofluorescence analysis of Hep3B cells. The cell was stained with EPHX1 monoclonal antibody, clone AT2E5 (1:100). The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).Enzyme-linked Immunoabsorbent Assay
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Gene Info — EPHX1
Entrez GeneID
2052Protein Accession#
NP_000111Gene Name
EPHX1
Gene Alias
EPHX, EPOX, MEH
Gene Description
epoxide hydrolase 1, microsomal (xenobiotic)
Gene Ontology
HyperlinkGene Summary
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene
Other Designations
OTTHUMP00000035867|epoxide hydratase|epoxide hydrolase 1|microsomal epoxide hydrolase
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Interactome
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Pathway
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Disease
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Publication Reference
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Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis.
van Loo B, Kingma J, Arand M, Wubbolts MG, Janssen DB.
Applied and Environmental Microbiology 2006 Apr; 72(4):2905.
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Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours.
Coller JK, Fritz P, Zanger UM, Siegle I, Eichelbaum M, Kroemer HK, Murdter TE.
The Histochemical journal 2001 Jun; 33(6):329.
Application:IHC-P, Human, Bronchus, Lung, Cerebrum, Kidney, Ovarian, Corpus carcinoma, Bladder, Testis, Lymph nodes.
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The human microsomal epoxide hydrolase gene (EPHX1): complete nucleotide sequence and structural characterization.
Hassett C, Robinson KB, Beck NB, Omiecinski CJ.
Genomics 1994 Sep; 23(2):433.
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Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis.
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