NRCAM monoclonal antibody, clone RNL-1
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Specification
Product Description
Mouse monoclonal antibody raised against native NRCAM.
Immunogen
Native purified NRCAM from NCI-H82 cell.
Host
Mouse
Reactivity
Human
Specificity
This antibody reacts with extracellular domain of the NRCAM.
Form
Liquid
Isotype
IgG1
Recommend Usage
Immunohistochemistry (1:10-1:25)
The optimal working dilution should be determined by the end user.Storage Buffer
In cell culture supernatant (0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Frozen sections)
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Gene Info — NRCAM
Entrez GeneID
4897Protein Accession#
P13591Gene Name
NRCAM
Gene Alias
KIAA0343, MGC138845, MGC138846
Gene Description
neuronal cell adhesion molecule
Omim ID
601581Gene Ontology
HyperlinkGene Summary
Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
NgCAM-related cell adhesion molecule|NrCAM-|bravo
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Interactome
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Pathway
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Disease
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Publication Reference
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Biodistribution of a monoclonal antibody (RNL-1) against the neural cell adhesion molecule (NCAM) in athymic mice bearing human small-cell lung-cancer xenografts.
Boerman OC, Mijnheere EP, Broers JL, Vooijs GP, Ramaekers FC.
International Journal of Cancer 1991 May; 48(3):457.
Application:Flow Cyt, IEM, IF, Human, Blood cells, NCI-H82 cells.
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Novel antigens characteristic of neuroendocrine malignancies.
Broers JL, Mijnheere EP, Rot MK, Schaart G, Sijlmans A, Boerman OC, Ramaekers FC.
Cancer 1991 Feb; 67(3):619.
Application:ICC, IEM, IF, IHC-Fr, WB-Ce, Human, HeLa cells, Human lung carcinoma cell lines, Human lung carcinoma, Human tissues, Human tumor tissues, LCLC-103H cells, NCI-H69, NCI-H82 cells.
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Biodistribution of a monoclonal antibody (RNL-1) against the neural cell adhesion molecule (NCAM) in athymic mice bearing human small-cell lung-cancer xenografts.
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