Receptor specificity of the TNFRSF10C monoclonal antibody, clone HS301 (Cat # MAB3479). CV1/EBNA cells were transfected either with the empty expression vector pCDNA3 (vector control) or pCDNA3 encoding TNFRSF10A to TNFRSF10D. Two days after transfection, 1 X 106 cells were stained with TNFRSF10C monoclonal antibody, clone HS301 (Cat # MAB3479).
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq
TNF related TRAIL receptor,TNF related apoptosis-inducing ligand receptor 3,TRAIL receptor 3,antagonist decoy receptor for TRAIL/Apo-2L,decoy receptor 1,decoy without an intracellular domain,lymphocyte inhibitor of TRAIL,tumor necrosis factor receptor sup