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Last updated: 2017/6/18
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TIRAP monoclonal antibody, clone Sebi-1

  • Catalog # : MAB3447
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  • Specification
  • Product Description:
  • Rat monoclonal antibody raised against partial recombinant TIRAP.
  • Immunogen:
  • Recombinant GST fusion protein corresponding to amino acids 1-215 of human TIRAP.
  • Host:
  • Rat
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes human TIRAP.
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Western Blot (1:500)
    Immunoprecipitation (1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunoprecipitation
  • Application Image
  • Western Blot
  • Immunoprecipitation
  • Gene Information
  • Gene Name:
  • TIRAP
  • Gene Alias:
  • FLJ42305,Mal,wyatt
  • Gene Description:
  • toll-interleukin 1 receptor (TIR) domain containing adaptor protein
  • Gene Summary:
  • The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
  • Other Designations:
  • MyD88 adapter-like protein,OTTHUMP00000179130,OTTHUMP00000179132,TIR domain-containing adapter protein,TIR domain-containing adaptor protein,Toll-interleukin 1 receptor (TIR) domain-containing adapter protein,Toll-interleukin 1 receptor (TIR) domain-conta
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