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Last updated: 2016/10/23
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XRCC5 monoclonal antibody, clone 111

  • Catalog # : MAB3426
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native XRCC5.
  • Immunogen:
  • Native purified XRCC5 from human B cell nuclei from plasmacytoid 2p68 cells.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Monkey
  • Specificity:
  • Reacts with the p80 Ku antigen subunit. Recognizes an epitope between amino acids 610-705 of p80. Does not react with bovine, rabbit, mouse or rat.
  • Form:
  • Liquid
  • Isotype:
  • IgG1, kappa
  • Recommend Usage:
  • Immunoprecipitation (2 ug/mg protein lysate)
    Western Blot (0.5-1.0 ug/mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 10 mM PBS, pH 7.4 (0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Immunofluorescence
  • Immunoprecipitation
  • Immunoprecipitation
  • Immunoprecipitation/Western blot analysis of XRCC5 expression in HeLa, BT747 and T-47D cells. Immunoprecipitation (native and denatured) using 2 ul/mg protein lysate. Use Protein G.
  • Flow Cytometry
  • Application Image
  • Immunofluorescence
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 7520
  • Gene Name:
  • XRCC5
  • Gene Alias:
  • FLJ39089,KARP-1,KARP1,KU80,KUB2,Ku86,NFIV
  • Gene Description:
  • X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • Gene Summary:
  • The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq
  • Other Designations:
  • ATP-dependent DNA helicase II,DNA repair protein XRCC5,Ku autoantigen, 80kDa,Ku86 autoantigen related protein 1,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kD),X-ray repair, comp
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