ABCB11 monoclonal antibody, clone USal-hBSEP-McAb-1
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Specification
Product Description
Mouse monoclonal antibody raised against synthetic peptide of ABCB11.
Immunogen
A synthetic peptide corresponding to amino acids 705-718 of human ABCB11.
Sequence
YLVHEPPLAVVDHK
Host
Mouse
Reactivity
Human
Specificity
Recognizes human SPGP. Does not cross-react with human P-glycoprotein.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 100 nM sodium azide
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
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Gene Info — ABCB11
Entrez GeneID
8647Gene Name
ABCB11
Gene Alias
ABC16, BSEP, PFIC-2, PFIC2, PGY4, SPGP
Gene Description
ATP-binding cassette, sub-family B (MDR/TAP), member 11
Gene Ontology
HyperlinkGene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq
Other Designations
ABC member 16, MDR/TAP subfamily|bile salt export pump|progressive familial intrahepatic cholestasis 2|sister p-glycoprotein
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