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Last updated: 2016/12/4
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ABCB11 monoclonal antibody, clone USal-hBSEP-McAb-1

  • Catalog # : MAB3415
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against synthetic peptide of ABCB11.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 705-718 of human ABCB11.
  • Sequence:
  • YLVHEPPLAVVDHK
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes human SPGP. Does not cross-react with human P-glycoprotein.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Western Blot (1:50-1:200)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In buffer containing 100 nM sodium azide
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunocytochemistry
  • Application Image
  • Western Blot
  • Immunocytochemistry
  • Gene Information
  • Entrez GeneID:
  • 8647
  • Gene Name:
  • ABCB11
  • Gene Alias:
  • ABC16,BSEP,PFIC-2,PFIC2,PGY4,SPGP
  • Gene Description:
  • ATP-binding cassette, sub-family B (MDR/TAP), member 11
  • Gene Summary:
  • The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq
  • Other Designations:
  • ABC member 16, MDR/TAP subfamily,bile salt export pump,progressive familial intrahepatic cholestasis 2,sister p-glycoprotein
  • Gene Pathway
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