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Last updated: 2017/7/16
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ABCC2 monoclonal antibody, clone M2II-12

  • Catalog # : MAB3383
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against partial recombinant ABCC2.
  • Immunogen:
  • Recombinant fusion protein corresponding to amino acids 860-950 of human ABCC2.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Reacts with an internal epitope of human cMOAT/MRP2. Does not cross-react with human MDR1, MRP1, MRP3, and MRP5 gene products.
  • Form:
  • Liquid
  • Isotype:
  • IgG2a
  • Recommend Usage:
  • Western Blot (1:20-50)
    Immunohistochemistry (Frozen sections) (1:20)
    Immunocytochemistry (1:20-1:50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In serum-free cell culture supernatant (0.09% sodium azide, 0.7% BSA)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot
  • Immunohistochemistry
  • Immunocytochemistry
  • Flow Cytometry
  • Application Image
  • Western Blot
  • Immunohistochemistry
  • Immunocytochemistry
  • Flow Cytometry
  • Gene Information
  • Entrez GeneID:
  • 1244
  • Gene Name:
  • ABCC2
  • Gene Alias:
  • ABC30,CMOAT,DJS,KIAA1010,MRP2,cMRP
  • Gene Description:
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • Gene Summary:
  • The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000020267,canalicular multispecific organic anion transporter
  • Gene Pathway
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