Flow cytometry detection of FASLG expression in stimulated H9 T cells (HUT-78). H9 T cells (1 X 106) were either left untreated (open histogram) or stimulated with 10 ng/mL PMA and 1 ug/mL ionomycin (filled histogram).
The protein encoded by this gene is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). [provided by RefSeq