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Last updated: 2017/10/15
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NLRP1 monoclonal antibody, clone Nalpy1-4

  • Catalog # : MAB3372
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant NLRP1.
  • Immunogen:
  • Recombinant protein corresponding to human NLRP1.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • Recognizes the pyrin domain (PYD) of human NAPL1.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Recommend Usage:
  • Western Blot (1:1000)
    Immunocytochemistry (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (0.02% sodium azide)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of the time course of assembly of the inflammasome with NLRP1 monoclonal antibody, clone Nalpy1-4 (Cat # MAB3372) in THP-1 macrophages.
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunocytochemistry
  • Immunofluorescence
  • Immunofluorescence
  • Detection of NALP1 in 293T cells transfected with a human NLRP1 expression plasmid.
    A : Phase contrast.
    B : Staining with antibody to NLRP1 monoclonal antibody, clone Nalpy1-4 (Cat # MAB3372).
  • Immunoprecipitation
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
  • Immunocytochemistry
  • Immunoprecipitation
  • Gene Information
  • Gene Name:
  • NLRP1
  • Gene Alias:
  • CARD7,CLR17.1,DEFCAP,DEFCAP-L/S,DKFZp586O1822,KIAA0926,NAC,NALP1,PP1044,SLEV1,VAMAS1
  • Gene Description:
  • NLR family, pyrin domain containing 1
  • Gene Summary:
  • This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq
  • Other Designations:
  • NACHT, LRR and PYD containing protein 1,NACHT, leucine rich repeat and PYD (pyrin domain) containing 1,NACHT, leucine rich repeat and PYD containing 1,caspase recruitment domain protein 7,death effector filament-forming Ced-4-like apoptosis protein,nucleo
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