Immunostaining of HEK-293T cells transfected with a mouse TNFSF13 expression plasmid (left panels) or mock transfected (right panel).
TNFSF13 monoclonal antibody, clone Sacha-1 (Cat # MAB3364) , detects membrane-bound human TNFSF13 by FACS. HEK 293T cells (5 X 105) were mock transfected (thin line) or transfected with an expression plasmid enabling surface expression of mouse TNFSF13 (thick line).
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Other transcripts that skip the last exon of the upstream gene (TNFSF12) and continue with the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq
OTTHUMP00000174780,TNF- and APOL-related leukocyte expressed ligand 2,a proliferation inducing ligand,tumor necrosis factor (ligand) superfamily member 13 transcript variant delta,tumor necrosis factor ligand superfamily member 13 epsilon,tumor necrosis f