IL5 monoclonal antibody, clone JES1-39D10
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Specification
Product Description
Rat monoclonal antibody raised against recombinant IL5.
Immunogen
Recombinant protein corresponding to human IL5.
Host
Rat
Reactivity
Human
Specificity
human Interleukin-5 (IL-5).
Form
Liquid
Isotype
IgG2a
Recommend Usage
Western Blot (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — IL5
Entrez GeneID
3567Gene Name
IL5
Gene Alias
EDF, IL-5, TRF
Gene Description
interleukin 5 (colony-stimulating factor, eosinophil)
Omim ID
147850Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq
Other Designations
B cell differentiation factor I|OTTHUMP00000065830|T-cell replacing factor|eosinophil differentiation factor|interleukin 5|interleukin-5
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Interactome
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Pathway
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Disease
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Publication Reference
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Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
Abrams JS, Roncarolo MG, Yssel H, Andersson U, Gleich GJ, Silver JE.
Immunological Reviews 2006 Jun; 127:5.
Application:Blocking, ELISA, Human, Supernatants from cells cultured and stimulated ex vivo with different agents and biological fluids like sera/plasma, bronehoalveolar lavage, ascites, urines, cerebrospinal fluids, saliva, and sputa. .
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Elevated serum levels of interleukin-5 in patients with the syndrome of episodic angioedema and eosinophilia.
Butterfield JH, Leiferman KM, Abrams J, Silver JE, Bower J, Gonchoroff N, Gleich GJ.
Blood 1992 Feb; 79(3):688.
Application:ELISA, Human, Human serum.
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Interleukin-5 and the posttreatment eosinophilia in patients with onchocerciasis.
Limaye AP, Abrams JS, Silver JE, Awadzi K, Francis HF, Ottesen EA, Nutman TB.
The Journal of Clinical Investigation 1991 Oct; 88(4):1418.
Application:Immunoenzymetric assays, Human, Serum.
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Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
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