BKV VP1 monoclonal antibody (M19), clone 5E6
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant BKV VP1.
Immunogen
BKV VP1 (YP_717939.1, 1 a.a. ~ 369 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MGTNSVDTAPTKRKGECPGAAPKKPKEPVQVPKLLIKGGVEVLEVKTGVDAITEVECFLNPEMGDPDENLRGFSLKLSAENGFSSDSPERKMLPCYSTARIPLPNLNEDLTCGNLLMWEAVTVQTEVIGITSMLNLHAGSQKVHEHGGGKPIQGSNFHFFAVGGDPLEMQGVLMNYRTKYPDGTITPKNPTAQSQVMNTDHKAYLDKNNAYPVECWVPDPSRNENTRYFGTFTGGENVPPVLHVTNTATTVLLDEQGVGPLCKADSLYVSAADICGLFTNSSGTQQWRGLARYFKIRLRKRSVKNPYPISFLLSDLINRRTQRVDGQPMYGMESQVEEVRVFDGTERLPGDPDMIRYIDKQGQLQTKML
Host
Mouse
Reactivity
Viruses
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (66.99 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunoperoxidase of monoclonal antibody to BKV VP1 on formalin-fixed paraffin-embedded human kidney. [antibody concentration 3 ug/ml]ELISA
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Gene Info — BKPyVgp4
Entrez GeneID
1489515GeneBank Accession#
NC_001538Protein Accession#
YP_717939.1Gene Name
BKPyVgp4
Gene Alias
VP1
Gene Description
VP1
Gene Ontology
HyperlinkOther Designations
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Publication Reference
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The essential role of the ERK activation in large T antigen of BK polyomavirus regulated cell migration.
Jiun-Wen Wang, Yi-Jung Li, Hsin-Hsu Wu, Hsiang-Hao Hsu, Ming-Yang Chang, Robert Yl Wang, Ya-Chung Tian.
Virus Research 2023 Oct; 336:199220.
Application:WB, Human, hRPTEC cells.
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Everolimus reduces BK polyomavirus infection by suppressing its replication and spread of infection.
Noriaki Sato, Atsuko Shiraki, Keita P Mori, Kaoru Sakai, Long Tan, Yoshinori Takemura, Yasushi Okuno, Kazunari Tanabe, Kimiyasu Shiraki.
Antiviral Research 2022 Dec; 208:105456.
Application:WB-Ce, Human, HEL cells.
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Acitretin and Retinoic Acid Derivatives Inhibit BK Polyomavirus Replication in Primary Human Proximal Renal Tubular Epithelial and Urothelial Cells.
Zongsong Wu, Fabrice E Graf, Hans H Hirsch.
Journal of Virology 2021 Jul; 95(15):e0012721.
Application:IF, WB-Ce, Human, Monkey, COS-7 cells, Primary human renal proximal tubular epithelial cells, Primary human urothelial cells.
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Single cell transcriptomics reveals a heterogeneous cellular response to BKV infection.
Ping An, Paul G Cantalupo, Wenshan Zheng, Maria Teresa Sáenz-Robles, Alexis M Duray, David Weitz, James M Pipas.
Journal of Virology 2021 Feb; 95(6):e02237.
Application:IF, Human, Human renal proximal tubule epithelial cells.
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BK Polyomavirus Evades Innate Immune Sensing by Disrupting the Mitochondrial Network and Promotes Mitophagy.
Julia Manzetti, Fabian H Weissbach, Fabrice E Graf, Gunhild Unterstab, Marion Wernli, Helmut Hopfer, Cinthia B Drachenberg, Christine Hanssen Rinaldo, Hans H Hirsch.
iScience 2020 Jul; 23(7):101257.
Application:WB-Tr, Human, Human renal proximal tubular epithelial cells.
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Human polyomavirus BKV infection of endothelial cells results in interferon pathway induction and persistence.
An P, Sáenz Robles MT, Duray AM, Cantalupo PG, Pipas JM.
PLoS Pathogens 2019 Jan; 15(1):e1007505.
Application:IF, WB, Human, Human lung microvascular endothelial cells.
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BK Polyomavirus Replication in Renal Tubular Epithelial Cells Is Inhibited by Sirolimus, but Activated by Tacrolimus Through a Pathway Involving FKBP-12.
Hirsch HH, Yakhontova K, Lu M, Manzetti J.
American Journal of Transplantation 2016 Mar; 16(3):821.
Application:IF, Human, Primary RPTEC cells.
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The essential role of the ERK activation in large T antigen of BK polyomavirus regulated cell migration.
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