Immunoblot analysis of cell lysates. Lane 1 : Bosc23 cell lysate. Lane 2 : Bosc23 cell lysate transfected with Myc/His/Tau (1-441 a. a.). Lane 3 : Bosc23 cell lysate transfected with Myc/His/PTPRT rho (887-1169 a. a.). Lane 4 : Bosc23 cell lysate transfected with GFP-Ubiquitin+1.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq
OTTHUMP00000031658,receptor protein tyrosine phosphatase