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Last updated: 2016/10/23
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PTPN2 monoclonal antibody, clone T25-AF3B7

  • Catalog # : MAB2739
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant PTPN2.
  • Immunogen:
  • Recombinant protein corresponding to human PTPN2.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Form:
  • Liquid
  • Purification:
  • Ammonium sulfate precipitation
  • Recommend Usage:
  • Western Blot (1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In HEPES, 150 mM NaCl (50% glycerol, 0.01% BSA, 0.03% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • Immunoblot analysis of cell lysates.
    Lane 1 : Bosc23 cell lysate.
    Lane 2 : Bosc23 cell lysate transfected with Myc/His/Tau (1-441 a. a.).
    Lane 3 : Bosc23 cell lysate transfected with Myc/His/PTPN2 (1-387E a. a.).
    Lane 4 : Bosc23 cell lysate transfected with GFP-Ubiquitin+1.
  • Application Image
  • Western Blot (Transfected lysate)
  • Western Blot (Transfected lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5771
  • Gene Name:
  • PTPN2
  • Gene Alias:
  • Gene Description:
  • protein tyrosine phosphatase, non-receptor type 2
  • Gene Summary:
  • The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq
  • Other Designations:
  • T-cell protein tyrosine phosphatase
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