Immunoblot analysis of cell lysates. Lane 1 : Bosc23 cell lysate. Lane 2 : Bosc23 cell lysate transfected with Myc/His/Tau (1-441 a. a.). Lane 3 : Bosc23 cell lysate transfected with Myc/His/PTPN14 (855-1187E a. a.). Lane 4 : Bosc23 cell lysate transfected with GFP-Ubiquitin+1.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined. [provided by RefSeq
OTTHUMP00000035094,cytoskeletal-associated protein tyrosine phosphatase