LAMB1 monoclonal antibody, clone DG10
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against partial native LAMB1.
Immunogen
Native purified human LAMB1.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes the Mr 220000 beta 1-chain of laminin. Mab DG10 appears to react with the NH2-terminus of the Ln beta 1-chain. This antibody reacts with human tissues. Clone DG 10 against laminin beta1-chain is apparently one of the few laminin antibodies working perfectly in immunoblotting.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Native Purified Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (1% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot
Immunohistochemistry (Frozen sections)
-
Gene Info — LAMB1
Entrez GeneID
3912Gene Name
LAMB1
Gene Alias
CLM, MGC142015
Gene Description
laminin, beta 1
Omim ID
150240Gene Ontology
HyperlinkGene Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq
Other Designations
cutis laxa with marfanoid phenotype
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Unaltered distribution of laminins, fibronectin, and tenascin in celiac intestinal mucosa.
Korhonen M, Ormio M, Burgeson RE, Virtanen I, Savilahti E.
The Journal of Histochemistry and Cytochemistry 2000 Jul; 48(7):1011.
Application:IF, IHC-Fr, Human, Human intestinal mucosa.
-
Muscle membrane-skeleton protein changes and histopathological characterization of muscle-eye-brain disease.
Auranen M, Rapola J, Pihko H, Haltia M, Leivo I, Soinila S, Virtanen I, Kalimo H, Anderson LV, Santavuori P, Somer H.
Neuromuscular Disorders 2000 Jan; 10(1):16.
Application:IF, Human, Muscle.
-
Blood platelets contain and secrete laminin-8 (alpha4beta1gamma1) and adhere to laminin-8 via alpha6beta1 integrin.
Geberhiwot T, Ingerpuu S, Pedraza C, Neira M, Lehto U, Virtanen I, Kortesmaa J, Tryggvason K, Engvall E, Patarroyo M.
Experimental Cell Research 1999 Dec; 253(2):723.
Application:IP, ELISA, WB-Ce, Human, Human platelets.
-
Unaltered distribution of laminins, fibronectin, and tenascin in celiac intestinal mucosa.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com