SPTB monoclonal antibody, clone DB2
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Specification
Product Description
Mouse monoclonal antibody raised against native SPTB.
Immunogen
Native purified human SPTB.
Host
Mouse
Reactivity
Human
Specificity
This antibody is specific to the 220kD human erythroid beta-spectrin. The protein is also present in the membranes of human skeletal muscle cells. Erythroid spectrins, some other proteins of erythroid cytoskeleton, and the transmembrane protein band 3 are highly specific to erythrocytes and their progenitors. They are more reliable markers for erythroid differentiation than Glycophorin A, the commonly used marker for erythroid differentiation, because Glycophorin A is expressed also in many cell lines otherwise exhibiting mainly megakaryotic charasteristics. Monoclonal antibody to erythroid beta-spectrin is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Native Purified Protein.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (1% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Immunoprecipitation
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Gene Info — SPTB
Entrez GeneID
6710Gene Name
SPTB
Gene Alias
HSpTB1
Gene Description
spectrin, beta, erythrocytic
Omim ID
182870Gene Ontology
HyperlinkGene Summary
beta
Other Designations
beta I spectrin form betaI sigma3|beta-spectrin|membrane cytoskeletal protein|spectrin beta|spectrin, beta, erythrocytic (includes sperocytosis, clinical type I)|spectrin, beta, erythrocytic (includes spherocytosis, clinical type I)|spherocytosis, clinica
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Interactome
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Disease
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Publication Reference
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Muscle membrane-skeleton protein changes and histopathological characterization of muscle-eye-brain disease.
Auranen M, Rapola J, Pihko H, Haltia M, Leivo I, Soinila S, Virtanen I, Kalimo H, Anderson LV, Santavuori P, Somer H.
Neuromuscular Disorders 2000 Jan; 10(1):16.
Application:IF, Human, Muscle.
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Expression of megakaryocytic and erythroid properties in human leukemic cells.
Tani T, Ylänne J, Virtanen I.
Exp Hematol 1996 Feb; 24(2):158.
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Muscle membrane-skeleton protein changes and histopathological characterization of muscle-eye-brain disease.
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