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Last updated: 2016/10/16
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KRT7/KRT17/KRT19 monoclonal antibody, clone 4F5

  • Catalog # : MAB2512
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against native KRT7/KRT17/KRT19.
  • Immunogen:
  • Native purified pig KRT7/KRT17/KRT19.
  • Host:
  • Mouse
  • Reactivity:
  • Human, Pig
  • Specificity:
  • This antibody recognizes cytokeratins nos. 7, 17 and 19 typical for many simple epithelial cells but is found also in cells in squamous epithelia. Monoclonal antibody to cytokeratin is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
  • Form:
  • Liquid
  • Isotype:
  • IgG1
  • Quality Control Testing:
  • Antibody Reactive Against Native Purified Protein.
  • Recommend Usage:
  • Western Blot (1:1000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS (1% BSA, 0.09% sodium azide)
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Application Image
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Gene Information
  • Entrez GeneID:
  • 3855
  • Gene Name:
  • KRT7
  • Gene Alias:
  • CK7,K2C7,K7,MGC129731,MGC3625,SCL
  • Gene Description:
  • keratin 7
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq
  • Other Designations:
  • cytokeratin 7,keratin, 55K type II cytoskeletal,keratin, simple epithelial type I, K7,keratin, type II cytoskeletal 7,sarcolectin,type II mesothelial keratin K7
  • Gene Information
  • Entrez GeneID:
  • 3872
  • Gene Name:
  • KRT17
  • Gene Alias:
  • K17,PC,PC2,PCHC1
  • Gene Description:
  • keratin 17
  • Gene Summary:
  • This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq
  • Other Designations:
  • cytokeratin-17
  • Gene Information
  • Entrez GeneID:
  • 3880
  • Gene Name:
  • KRT19
  • Gene Alias:
  • CK19,K19,K1CS,MGC15366
  • Gene Description:
  • keratin 19
  • Gene Summary:
  • The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq
  • Other Designations:
  • 40-kDa keratin intermediate filament,cytokeratin 19,keratin, type I cytoskeletal 19,keratin, type I, 40-kd
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