TGFB1 monoclonal antibody, clone TB21
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Specification
Product Description
Mouse monoclonal antibody raised against native TGFB1.
Immunogen
Native purified human TGFB1.
Host
Mouse
Theoretical MW (kDa)
25, 12.5
Reactivity
Human, Rat
Specificity
Western blotting demonstrated that this antibody reacts with the dimeric (25 KDa) and monomeric (12.5 KDa) forms of TGFB1 under both non-reducing and reducing conditions respectively. This antibody recognizes both human platelet-derived and recombinant TGFB1 in ELISA.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Native Purified Protein.
Recommend Usage
Western Blot (5-20 ng/mL)
Immunohistochemistry (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Enzyme Immunoassay
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Gene Info — TGFB1
Entrez GeneID
7040Gene Name
TGFB1
Gene Alias
CED, DPD1, TGFB, TGFbeta
Gene Description
transforming growth factor, beta 1
Gene Ontology
HyperlinkGene Summary
TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM
Other Designations
TGF-beta 1 protein|diaphyseal dysplasia 1, progressive|transforming growth factor-beta 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Evaluation of TGFβ, XPO4, elF5A2 and ANGPTL4 as biomarkers in HCC.
Zhang H, Wei S, Ning S, Jie Y, Ru Y, Gu Y.
Experimental and Therapeutic Medicine 2012 Oct; 5(1):119.
Application:IHC, Human, Human hepatocellular carcinoma.
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Thrombospondin-1 is a major activator of TGF-beta1 in vivo.
Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SM, Lawler J, Hynes RO, Boivin GP, Bouck N.
Cell 1998 Jun; 93(7):1159.
Application:IHC-P, Mouse, Gall bladder, Heart, Kidney.
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Evaluation of TGFβ, XPO4, elF5A2 and ANGPTL4 as biomarkers in HCC.
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