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Last updated: 2016/12/4
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LMNA monoclonal antibody, clone JOL4

  • Catalog # : MAB2501
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  • Specification
  • Product Description:
  • Mouse monoclonal antibody raised against recombinant LMNA.
  • Immunogen:
  • Recombinant protein corresponding to human LMNA.
  • Host:
  • Mouse
  • Reactivity:
  • Human
  • Specificity:
  • This antibody reacts with both recombinant and native LMNA in humans, binding to an epitope between amino acids 572-646.
  • Form:
  • Liquid
  • Isotype:
  • IgG
  • Quality Control Testing:
  • Antibody Reactive Against Recombinant Protein.
  • Recommend Usage:
  • Western Blot (1:50)
    Immunoprecipitation (1:50)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 200 mM Tris-HCl, pH 7.4 (5-10% FCS)
  • Storage Instruction:
  • Store at 4°C. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Publication Reference
  • Applications
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Immunofluorescence
  • Immunoprecipitation
  • Application Image
  • Western Blot
  • Immunohistochemistry (Frozen sections)
  • Immunofluorescence
  • Immunoprecipitation
  • Gene Information
  • Entrez GeneID:
  • 4000
  • Gene Name:
  • LMNA
  • Gene Alias:
  • CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,HGPS,IDC,LDP1,LFP,LGMD1B,LMN1,LMNC,PRO1
  • Gene Description:
  • lamin A/C
  • Gene Summary:
  • The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
  • Other Designations:
  • 70 kDa lamin,OTTHUMP00000015843,OTTHUMP00000015848
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