EME1 monoclonal antibody, clone 7h2/1
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Specification
Product Description
Mouse monoclonal antibody raised against EME1.
Immunogen
Human EME1.
Host
Mouse
Reactivity
Human
Specificity
human EME1.
Form
Liquid
Isotype
IgG1
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
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Gene Info — EME1
Entrez GeneID
146956Gene Name
EME1
Gene Alias
FLJ31364, MMS4L
Gene Description
essential meiotic endonuclease 1 homolog 1 (S. pombe)
Omim ID
610885Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability
Other Designations
essential meiotic endonuclease 1 homolog 1|essential meiotic endonuclease 1 homolog 2|homolog of yeast EME1 endonuclease
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Interactome
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Pathway
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Disease
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Publication Reference
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The EGFR-STAT3 oncogenic pathway up-regulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibition.
Vigneron A, Gamelin E, Coqueret O.
Cancer Research 2008 Feb; 68(3):815.
Application:WB, Human, HCT-116 cells.
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The EGFR-STAT3 oncogenic pathway up-regulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibition.
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